A new chemical tool for exploring the physiological function of the PDE2 isozyme

Autor:	A. Samuel Vellekoop, Douglas A. Otte, R. J. Chambers, Norman Y. Garceau, David A. Tess, Ajith V. Kamath, Christopher M. Manley, Alissa L. Sheils, Susan C. Lilley, Kelvin Lam, Dennis O. Scott, Kristin Abrams, Yan Zhang
Rok vydání:	2005
Předmět:	Indoles Phosphodiesterase Inhibitors Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Administration Oral Biochemistry Isozyme chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Animals Oxindole Molecular Biology ADME Physiological function Molecular Structure Phosphoric Diester Hydrolases Adenine fungi Organic Chemistry Cyclic Nucleotide Phosphodiesterases Type 2 Oxindoles Rats Isoenzymes chemistry Solubility Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 16(2)
ISSN:	0960-894X
Popis:	Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd92f67fa405782ff8ca80f9872d12b https://pubmed.ncbi.nlm.nih.gov/16275071 Zobrazit plný text záznamu Full Text from ScienceDirect