Complex Evolution of the Mismatch Repair System in Eukaryotes is Illuminated by Novel Archaeal Genomes
| Autor: | Daniel J. G. Lahr, Paulo G. Hofstatter |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Eukaryotes
DNA repair DNA damage Computational biology mutL DNA Mismatch Repair Genome Mismatch repair 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Meiosis Genome Archaeal mutS Gene duplication Genetics Asgard Archaea Molecular Biology Ecology Evolution Behavior and Systematics 030304 developmental biology REPARAÇÃO DE DNA 0303 health sciences biology Eukaryota biology.organism_classification Archaea Eukaryotic Cells chemistry Original Article DNA mismatch repair 030217 neurology & neurosurgery DNA |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Journal of Molecular Evolution |
| ISSN: | 1432-1432 0022-2844 |
| DOI: | 10.1007/s00239-020-09979-5 |
| Popis: | Repairing DNA damage is one of the most important functions of the ‘housekeeping’ proteins, as DNA molecules are constantly subject to different kinds of damage. An important mechanism of DNA repair is the mismatch repair system (MMR). In eukaryotes, it is more complex than it is in bacteria or Archaea due to an inflated number of paralogues produced as a result of an extensive process of gene duplication and further specialization upon the evolution of the first eukaryotes, including an important part of the meiotic machinery. Recently, the discovery and sequencing of Asgard Archaea allowed us to revisit the MMR system evolution with the addition of new data from a group that is closely related to the eukaryotic ancestor. This new analysis provided evidence for a complex evolutionary history of eukaryotic MMR: an archaeal origin for the nuclear MMR system in eukaryotes, with subsequent acquisitions of other MMR systems from organelles. Supplementary Information The online version of this article (10.1007/s00239-020-09979-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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