Clustering of Brugia malayi infection in a community in South-Sulawesi, Indonesia
| Autor: | K. Abadi, Y. Ruiterman, Maria Yazdanbakhsh, M. Haarbrink, A. J. Terhell, Jeanine J. Houwing-Duistermaat |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Adolescent Helminthiasis Enzyme-Linked Immunosorbent Assay Biology Parasitemia Microfilaria Statistics Nonparametric Brugia malayi Genetic determinism Filariasis Elephantiasis Filarial parasitic diseases Prevalence medicine Animals Cluster Analysis Humans Genetic Predisposition to Disease Child Microfilariae Lymphatic filariasis Family aggregation Middle Aged medicine.disease biology.organism_classification Pedigree Infectious Diseases Indonesia Antigens Helminth Immunoglobulin G Immunology Population study Female Animal Science and Zoology Parasitology Demography |
| Zdroj: | Parasitology. 120:23-29 |
| ISSN: | 1469-8161 0031-1820 |
| Popis: | The present study was undertaken in village Karondang in South-Sulawesi, Indonesia, to investigate the influences of genetic, household and environmental factors on Brugia malayi infection. Infection status was determined by measuring both microfilariae in night blood and anti-filarial IgG4, as a marker for detection of active filarial infection. A total of 171 residents participated in the study; familial relationships between subjects were registered to construct pedigrees and distances between households were measured. The data were analysed using a test statistic for familial aggregation. For distribution of microfilariae over the study population a genetic influence on infection susceptibility was favoured over the household and environmental effects. For anti-filarial IgG4, all 3 clustering models gave significant results, suggesting that genetic, household and/or environmental factors influence specific IgG4 antibodies. |
| Databáze: | OpenAIRE |
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