A lateralized model of the pain-depression dyad
| Autor: | Christine B. Sieberg, David Borsook, Scott A. Holmes, Eric A. Moulton, Donald B. Giddon, Anne Margarette S. Maallo |
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| Rok vydání: | 2021 |
| Předmět: |
business.industry
Depression Cognitive Neuroscience Chronic pain medicine.disease Mental illness Lateralization of brain function Article Psychological evaluation Behavioral Neuroscience Neuropsychology and Physiological Psychology Nociception medicine Humans Chronic Pain business Association (psychology) Depression (differential diagnoses) Dyad Clinical psychology |
| Zdroj: | Neurosci Biobehav Rev |
| ISSN: | 1873-7528 |
| Popis: | Chronic pain and depression are two frequently co-occurring and debilitating conditions. Even though the former is treated as a physical affliction, and the latter as a mental illness, both disorders closely share neural substrates. Here, we review the association of pain with depression, especially when symptoms are lateralized on either side of the body. We also explore the overlapping regions in the forebrain implicated in these conditions. Finally, we synthesize these findings into a model, which addresses gaps in our understanding of comorbid pain and depression. Our lateralized pain-depression dyad model suggests that individuals diagnosed with depression should be closely monitored for pain symptoms in the left hemibody. Conversely, for patients in pain, with the exception of acute pain with a known source, referrals in today's pain centers for psychological evaluation should be part of standard practice, within the framework of an interdisciplinary approach to pain treatment. |
| Databáze: | OpenAIRE |
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