Pressure-Sensitive Adhesive Combined with Paper Spray Mass Spectrometry for Low-Cost Collection and Analysis of Drug Residues
| Autor: | Ethan M. McBride, Elizabeth S. Dhummakupt, William R. A. Wichert, Chau Bao Nguyen, Phillip M. Mach, Trevor Glaros, Nicholas E. Manicke, Daniel O. Carmany |
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| Rok vydání: | 2021 |
| Předmět: |
Paper
Drug Chromatography Illicit Drugs Chemistry media_common.quotation_subject Mass spectrometry Rapid detection Drug Residues Mass Spectrometry Designer Drugs Analytical Chemistry Benzodiazepines Limit of Detection Adhesives Pressure sensitive Clonazolam Ion trap Adhesive Sample collection media_common |
| Zdroj: | Analytical Chemistry. 93:13467-13474 |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/acs.analchem.1c02050 |
| Popis: | Illicit drug use causes over half a million deaths worldwide every year. Drugs of abuse are commonly smuggled through customs and border checkpoints and, increasingly, through parcel delivery services. Improved methods for detection of trace drug residues from surfaces are needed. Such methods should be robust, fieldable, sensitive, and capable of detecting a wide range of drugs. In this work, commercially produced paper with a pressure-sensitive adhesive coating was utilized for the collection and analysis of trace drug residues by paper spray mass spectrometry (MS). This modified substrate was used to combine sample collection of drug residues from surfaces with rapid detection using a single paper spray ticket. The all-in-one ticket was used to probe different surfaces commonly encountered in forensic work including clothing, cardboard, glass, concrete, asphalt, and aluminum. A total of 10 drugs (acetyl fentanyl, fentanyl, clonazolam, cocaine, heroin, ketamine, methamphetamine, methylone, U-47700, and XLR-11) were evaluated and found to be detectable in the picogram range using a benchtop mass spectrometer and in the low nanogram range using a portable ion trap MS. The novel approach demonstrates a simple yet effective sampling strategy, allowing for rapid identification from difficult surfaces via paper spray mass spectrometry. |
| Databáze: | OpenAIRE |
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