Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan
| Autor: | Hajime Nawata, Kunihisa Kobayashi, Toyoshi Inoguchi, Naotaka Sekiguchi, Noriyuki Sonoda |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Immunoprecipitation Biophysics Electrophoretic Mobility Shift Assay Biochemistry LDL binding chemistry.chemical_compound Internal medicine Biglycan medicine Molecular Biology Extracellular Matrix Proteins Dose-Response Relationship Drug biology Adiponectin nutritional and metabolic diseases Cell Biology Lipoproteins LDL Endocrinology Proteoglycan chemistry Low-density lipoprotein biology.protein Intercellular Signaling Peptides and Proteins Proteoglycans hormones hormone substitutes and hormone antagonists Protein Binding Hormone |
| Zdroj: | Biochemical and Biophysical Research Communications. 335:66-70 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2005.07.048 |
| Popis: | The aim of this study was to test the possibility that adiponectin has an antiatherogenic effect through the inhibition of LDL binding to proteoglycans, an initial event in atherogenesis. Both full-length and globular adiponectin inhibited LDL binding in a dose-dependent manner. Both types of adiponectin bound to biglycan in a dose-dependent manner. Immunoprecipitation and immunoblotting analysis showed interaction of full-length adiponectin with LDL. Pretreatment of biglycan with globular adiponectin prior to LDL addition diminished the inhibitory effect, while pretreatment with full-length adiponectin retained the effect. This is a new antiatherogenic property that appears independent of the receptor-mediated hormonal action of adiponectin. |
| Databáze: | OpenAIRE |
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