Does Sucrose Change Its Mechanism of Stabilization of Lipid Bilayers during Desiccation? Influences of Hydration and Concentration
| Autor: | Ricardo L. Mancera, Sławomir S. Stachura, Chris J. Malajczuk |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Sucrose
02 engineering and technology Surfaces and Interfaces 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Electrochemistry Molecular mechanism Biophysics General Materials Science 0210 nano-technology Lipid bilayer Desiccation Spectroscopy Mechanism (sociology) |
| Zdroj: | Langmuir. 35:15389-15400 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/acs.langmuir.9b03086 |
| Popis: | Sugar-membrane interactions are believed to be responsible for cell preservation during desiccation and freezing, but the molecular mechanism by which they achieve this is still not well understood. The associated decrease of the main phase transition temperature of phospholipid bilayers is explained by two opposing views on the matter: the direct sugar-phospholipid interaction at the bilayer interface (water replacement hypothesis) and an entropy-driven phase transition with sugar molecules concentrating away from the lipid interface (hydration forces explanation). Both mechanisms are supported by experiments but molecular dynamics (MD) simulations have overwhelmingly shown the occurrence of direct sugar-phospholipid interactions. We have performed MD simulations of 1,2-dioleoyl |
| Databáze: | OpenAIRE |
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