Emerging evidence for accelerated ageing and cardiovascular disease in individuals with cerebral palsy
| Autor: | Patrick G. McPhee, Jan Willem Gorter, Maureen J. MacDonald, Emily C. Dunford, Jem L. Cheng |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Aging 030506 rehabilitation medicine.medical_specialty Population Physical Therapy Sports Therapy and Rehabilitation Cerebral palsy 03 medical and health sciences Risk Factors Internal medicine medicine Humans Longitudinal Studies education Pulse wave velocity education.field_of_study business.industry Cerebral Palsy Rehabilitation Gross Motor Function Classification System General Medicine medicine.disease Confidence interval Blood pressure Intima-media thickness Cardiovascular Diseases Arterial stiffness Cardiology Female 0305 other medical science business |
| Zdroj: | Journal of Rehabilitation Medicine. 51:525-531 |
| ISSN: | 1650-1977 |
| DOI: | 10.2340/16501977-2564 |
| Popis: | OBJECTIVE To examine longitudinal changes in traditional and non-traditional risk factors for cardiovascular disease in individuals with cerebral palsy and to investigate relationships between age, Gross Motor Function Classification System (GMFCS) and risk of cardiovascular disease. METHODS Individuals with cerebral palsy (n = 28 of 53 eligible participants; GMFCS levels I-V; follow-up mean age 35.1 years (standard deviation (SD) 14.4) participated in a longitudinal cohort study with 4.0 years (SD 1.2) follow-up. Traditional risk factors included waist circumference and systolic blood pressure. Non-traditional risk factors included carotid artery intima media thickness and distensibility, carotid-femoral pulse wave velocity, and flow-mediated dilation. RESULTS Absolute (0.31 mm (SD 0.13) vs 0.22 mm (SD 0.08) , p = 0.045, 95% confidence interval (95% CI) 0.040, 0.151) and relative flow-mediated dilation (9.9 % (SD 4.7) vs 7.5 % (SD 2.6), p = 0.049, 95% CI 0.464, 4.42) decreased, while carotid artery intima media thickness (0.52 mm (SD 0.17) vs 0.67 mm (SD 0.33), p = 0.041, 95% CI -0.242, -0.074) increased from baseline to follow-up. No other risk factor changed significantly. Age at baseline was a significant independent predictor of carotid artery intima media thickness change (R-squared = 0.261, p = 0.031). CONCLUSION Individuals with cerebral palsy experience significant changes in non-traditional risk factors for cardiovascular disease over 4 years, in the face of no changes in traditional risk factors. Compared with findings in the literature from the general population, these risk factors progress at a faster rate and at a younger age in individuals with cerebral palsy. |
| Databáze: | OpenAIRE |
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