Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib
| Autor: | Kaname Yamashita, Kazuo Yasumoto, Hisatsugu Mouri, Satoshi Kitagawa, Shinji Takeuchi, Kouji Izumi, Tadaaki Yamada, Peter I. Ghenev, Seiji Yano, Koushiro Ohtsubo |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Indoles Lung Neoplasms Antineoplastic Agents Hemorrhage Adverse effect urologic and male genital diseases Papillary renal cell carcinoma Renal cell carcinoma Sunitinib Humans Medicine Pyrroles Carcinoma Renal Cell Aged Lung medicine.diagnostic_test Papillary renal cell carcinomas business.industry Diffuse alveolar hemorrhage Hematology General Medicine respiratory system medicine.disease Kidney Neoplasms female genital diseases and pregnancy complications Pulmonary Alveoli Bronchoalveolar lavage medicine.anatomical_structure Oncology Sputum Surgery Pulmonary hemorrhage Vascular endothelial growth factor medicine.symptom Tomography X-Ray Computed business Bronchoalveolar Lavage Fluid Alveolar hemorrhage medicine.drug |
| Zdroj: | International Journal of Clinical Oncology. 15:638-641 |
| ISSN: | 1437-7772 1341-9625 |
| DOI: | 10.1007/s10147-010-0104-3 |
| Popis: | 金沢大学附属病院がん高度先進治療センター We report the case of a 67-year-old man with metastatic papillary renal cell carcinoma (RCC) who developed bloody sputum after the administration of sunitinib. Chest computed tomography revealed diffuse ground-glass opacity lesions, and bloody bronchoalveolar lavage fluid was obtained by flexible bronchoscopy. The abnormal shadows promptly regressed after withdrawal of sunitinib. In four cycles of sunitinib treatment, he suffered from controllable diffuse alveolar hemorrhage. Finally, he died of respiratory failure 8 months after onset. This is the first case report of diffuse alveolar hemorrhage as an adverse effect of sunitinib in metastatic papillary RCC. Care should be taken with pulmonary hemorrhage in the use of anti-angiogenesis agents in not only squamous cell lung cancer, but also metastatic lung tumors. © 2010 Japan Society of Clinical Oncology. |
| Databáze: | OpenAIRE |
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