NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma

Autor: Marie Wislez, Michael Duruisseaux, Virginie Poulot, Anne McLeer-Florin, Roger Lacave, Martine Antoine, Sanaz Alavizadeh, Jacques Cadranel, Nathalie Rabbe
Přispěvatelé: Theranoscan, Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie = Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Anatomie et cytologie pathologiques [CHU Tenon], Plateforme de Génomique des Tumeurs Solides [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), HAL-UPMC, Gestionnaire, Service de Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'anatomie pathologique [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Male
Cancer Research
Lung Neoplasms
Oncogene Proteins
Fusion
medicine.disease_cause
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Cohort Studies
0302 clinical medicine
In Situ Hybridization
Fluorescence
Cancer Biology
Aged
80 and over
Middle Aged
Adenocarcinoma
Mucinous
Immunohistochemistry
3. Good health
invasive mucinous adenocarcinoma
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Adenocarcinoma
Fish
Female
KRAS
medicine.medical_specialty
Neuregulin-1
Short Report
Adenocarcinoma of Lung
[SDV.CAN]Life Sciences [q-bio]/Cancer
03 medical and health sciences
molecular oncology
[SDV.CAN] Life Sciences [q-bio]/Cancer
FISH
Internal medicine
mental disorders
ROS1
medicine
Biomarkers
Tumor
Humans
Radiology
Nuclear Medicine and imaging
In patient
Neoplasm Invasiveness
Aged
NRG1
Lung
Oncogene
business.industry
medicine.disease
lung adenocarcinoma
030104 developmental biology
Mutation
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
business
Zdroj: Cancer Medicine
Cancer Medicine, 2016, ⟨10.1002/cam4.838⟩
Cancer Medicine, Wiley, 2016, ⟨10.1002/cam4.838⟩
ISSN: 2045-7634
Popis: International audience; Invasive mucinous lung adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma with no effective treatment option in advanced disease. KRAS mutations occur in 28–87% of the cases. NRG1 fusions were recently discovered in KRAS-negative IMA cases and otherwise negative for known driver oncogenes and could represent an attractive therapeutic target. Published data suggest that NRG1 fusions occur essentially in nonsmoking Asian women. From an IMA cohort of 25 French patients of known ethnicity, driver oncogenes EGFR, KRAS, BRAF, ERBB2 mutations, and ALK and ROS1 rearrangements presence were analyzed. In the IMA samples remaining negative for these driver oncogenes, an NRG1 rearrangement detection was performed by FISH. A driver oncogene was identified in 14/25 IMA, namely 12 KRAS mutations (48%), one ROS1 rearrangement (4%), and one ALK rearrangement (4%). The detection of NRG1 rearrangement by FISH was conducted in the 11 pan-negative IMA. One sample was NRG1FISH-positive and 100% of the tumor nuclei analyzed were positive. This NRG1-positive patient was a 61-year-old nonsmoking woman of Vietnamese ethnicity and was the sole patient of Asian ethnicity of the cohort. She died 6 months after the diagnosis with a pulmonary multifocal disease. NRG1FISH detection should be considered in patients with IMA pan-negative for known driver oncogenes. These results might suggest that NRG1 fusion is more frequent in IMA from Asian patient. Larger studies are needed.
Databáze: OpenAIRE
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