Interleukin-8 CSF levels predict survival in patients with leptomeningeal metastases
| Autor: | Emile E. Voest, T. Korse, Ale Algra, W. de Jager, J. C. Reijneveld, Hans Bonfrer, Dieta Brandsma, Ger T. Rijkers, M. J. B. Taphoorn, M. M. Verbeek, Willem Boogerd |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Pathology medicine.medical_treatment Neuroinformatics [DCN 3] Metastasis Sex Factors Cerebrospinal fluid Cognitive neurosciences [UMCN 3.2] Predictive Value of Tests Internal medicine Meningeal Neoplasms Perception and Action [DCN 1] medicine Humans In patient Survivors Interleukin 8 Alzheimer Centre [NCEBP 11] Survival analysis Aged Immunoassay business.industry Interleukin-8 Interleukin Middle Aged Prognosis medicine.disease Survival Analysis Cytokine Genetic defects of metabolism [UMCN 5.1] Predictive value of tests Pia Mater Female Neurology (clinical) Arachnoid business |
| Zdroj: | Neurology, 66, 2, pp. 243-6 Neurology, 66, 243-6 |
| ISSN: | 0028-3878 |
| Popis: | Contains fulltext : 50834.pdf (Publisher’s version ) (Closed access) Median survival of patients with leptomeningeal metastases (LM) is 4 to 6 months, with a few long-term survivors. Current prognostic factors for survival have limited value. The authors measured the CSF levels of nine inflammatory proteins in 57 patients with LM and determined their prognostic value. High interleukin (IL)-8 CSF levels predicted short-term survival independently. The data indicate that IL-8 CSF levels may serve as a prognosticator in patients with LM, but prospective validation is needed. |
| Databáze: | OpenAIRE |
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