What should we know about metabolic syndrome and lipodystrophy in AIDS?
| Autor: | Dario Hart Signorini, Walter de Araujo Eyer-Silva, Marion de Fátima Castro de Andrade, Michelle Carreira Miranda Monteiro, Dario Jose Hart Pontes Signorini |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Adolescent Lipodystrophy Cross-sectional study Anti-HIV Agents síndrome de lipodistrofia associada ao HIV antiretroviral therapy highly active cross-sectional studies estudos transversais HIV Infections Disease síndrome x metabólica Young Adult Acquired immunodeficiency syndrome (AIDS) Metabolic syndrome X Risk Factors Internal medicine Antiretroviral Therapy Highly Active medicine Prevalence risk factors Humans General Environmental Science Aged Metabolic Syndrome Fatores de risco business.industry HIV-Associated Lipodystrophy Syndrome Hypertriglyceridemia HIV HIV-associated lipodystrophy syndrome General Medicine Middle Aged medicine.disease Cross-Sectional Studies Population study General Earth and Planetary Sciences Female Metabolic syndrome business terapia antirretroviral de alta atividade |
| Zdroj: | Revista da Associação Médica Brasileira v.58 n.1 2012 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB |
| ISSN: | 1806-9282 |
| Popis: | OBJECTIVE: Prevalence of chronic complications of HIV infection is increasing and early recognition and treatment of the components of metabolic syndrome (MS) are essential to prevent cardiovascular and metabolic complications. Considering this, we performed a cross-sectional study on the prevalence and risk-factors for MS among HIV-infected subjects. METHODS: A total of 819 patients followed at a large outpatient HIV unit were assessed by an interviewer-administered questionnaire that recorded several demographic, epidemiologic, clinical, laboratory, and social variables. Lipodystrophy diagnosis relied on agreement between patient's self-report and physician's observation of altered body-fat deposits. The presence of three or more of the following characteristics identified MS: increased waist circumference, hypertriglyceridemia, low HDL cholesterol level, hypertension, and hyperglycemia. We used logistic regression analyses to study variables independently associated with MS. RESULTS: The prevalence of MS was 20.6% and that of lipodystrophy was 38.5%. 61 (36.1%) out of 169 patients with MS had also lipodystrophy. Patients with metabolic syndrome were significantly more likely to be older (OR = 1.08), had higher CD4 counts (OR = 1.001), had an increased body mass index (OR = 1.27) and had longer exposure to antiretroviral therapy (OR = 1.01) than those without metabolic syndrome. CONCLUSION: Both traditional risk factors for cardiovascular disease and factors associated with HIV infection itself, such as an increased CD4 cell count and a longer exposure to antiretroviral therapy, seem to be associated with metabolic syndrome in the present study population. |
| Databáze: | OpenAIRE |
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