Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population
| Autor: | Ramatu Wuni, Evelyn Adela Nathania, Ashok K. Ayyappa, Nagarajan Lakshmipriya, Kandaswamy Ramya, Rajagopal Gayathri, Gunasekaran Geetha, Ranjit Mohan Anjana, Gunter G. C. Kuhnle, Venkatesan Radha, Viswanathan Mohan, Vasudevan Sudha, Karani Santhanakrishnan Vimaleswaran |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Nutrition and Dietetics Fatty Acids India Middle Aged genetic risk score Asian Indians lipids central obesity fat intake gene-diet interaction saturated fatty acid Dietary Fats Polymorphism Single Nucleotide Cholesterol Ester Transfer Proteins Diet Lipoprotein Lipase Diabetes Mellitus Type 2 Risk Factors Obesity Abdominal Humans Female Waist Circumference Alleles Food Science |
| Zdroj: | Nutrients; Volume 14; Issue 13; Pages: 2713 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14132713 |
| Popis: | Abnormalities in lipid metabolism have been linked to the development of obesity. We used a nutrigenetic approach to establish a link between lipids and obesity in Asian Indians, who are known to have a high prevalence of central obesity and dyslipidaemia. A sample of 497 Asian Indian individuals (260 with type 2 diabetes and 237 with normal glucose tolerance) (mean age: 44 ± 10 years) were randomly chosen from the Chennai Urban Rural Epidemiological Study (CURES). Dietary intake was assessed using a previously validated questionnaire. A genetic risk score (GRS) was constructed based on cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL) genetic variants. There was a significant interaction between GRS and saturated fatty acid (SFA) intake on waist circumference (WC) (Pinteraction = 0.006). Individuals with a low SFA intake (≤23.2 g/day), despite carrying ≥2 risk alleles, had a smaller WC compared to individuals carrying 23.2 g/day) was significantly associated with a larger WC than a low SFA intake (≤23.2 g/day) (Beta = 0.02 cm, p = 0.02). There were no significant interactions between GRS and other dietary factors on any of the measured outcomes. We conclude that a diet low in SFA might help reduce the genetic risk of central obesity confirmed by CETP and LPL genetic variants. Conversely, a high SFA diet increases the genetic risk of central obesity in Asian Indians. |
| Databáze: | OpenAIRE |
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