Decreased Cognitive Functioning After Electroconvulsive Therapy Is Related to Increased Hippocampal Volume: Exploring the Role of Brain Plasticity
| Autor: | Joost G. E. Janzing, Rogier Donders, Aart H. Schene, Philip van Eijndhoven, Maria H. C. T. van Beek, Indira Tendolkar, Elke Butterbrod, Iris van Oostrom |
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| Přispěvatelé: | Cognitive Neuropsychology |
| Rok vydání: | 2018 |
| Předmět: |
Male
Wechsler Memory Scale Cognition Disorders/etiology medicine.medical_treatment Medizin Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Audiology Neuropsychological Tests Hippocampus Magnetic Resonance Imaging/methods Depressive Disorder Treatment-Resistant 0302 clinical medicine Electroconvulsive therapy Cognition Longitudinal Studies Prospective Studies Electroconvulsive Therapy Treatment-Resistant/therapy Neuronal Plasticity Neuropsychology Middle Aged Magnetic Resonance Imaging Psychiatry and Mental health Treatment Outcome Major depressive disorder Female Hippocampus/diagnostic imaging Adult Elementary cognitive task medicine.medical_specialty Neuroscience (miscellaneous) Verbal learning behavioral disciplines and activities 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center medicine Humans Effects of sleep deprivation on cognitive performance Psychiatric Status Rating Scales Depressive Disorder Depressive Disorder Treatment-Resistant/therapy business.industry Other Research Radboud Institute for Health Sciences [Radboudumc 0] Neuronal Plasticity/physiology medicine.disease Electroconvulsive Therapy/adverse effects 030227 psychiatry business Cognition Disorders 030217 neurology & neurosurgery |
| Zdroj: | Journal of Ect, 34, 2, pp. 117-123 Journal of Ect, 34, 117-123 The Journal of ECT, 34(2). Lippincott Williams and Wilkins Ltd. |
| ISSN: | 1095-0680 |
| Popis: | Objective: Electroconvulsive therapy (ECT) is still the most effective treatment of severe and therapy-refractory major depressive disorder. Cognitive side effects are the major disadvantage of ECT. Cognitive deficits are generally temporary in nature and may be mediated by the hippocampus. Recent studies have shown a temporary increase in hippocampal volume and a temporary decrease in cognitive functioning post-ECT compared with pre-ECT. This study investigates whether these volumetric changes are related to changes in cognitive functioning after ECT.Methods: Nineteen medication-free patients with treatment-resistant major depressive disorder underwent a whole-brain magnetic resonance imaging scan and a neuropsychological examination (including the Rey auditory verbal learning task, Wechsler Memory Scale Visual Reproduction, fluency, Trail Making Task) within 1 week before and within 1 week after the course of ECT. Electroconvulsive therapy was administered twice a week bitemporally with a brief pulse. A matched healthy control group (n = 18) received the same neuropsychological examination and at a similar interval to that of the patients.Results: Hippocampal volumes increased significantly from pretreatment to posttreatment in patients. Mean performance on cognitive tasks declined, or remained stable, whereas performance in controls generally improved because of retesting effects. The increase in hippocampal volume was related to changes in cognitive performance, indicating that this increase co-occurred with a decrease in cognitive functioning.Conclusions: Our findings tentatively suggest that the temporal increase in hippocampal volume after treatment, which may result from neurotrophic processes and is thought to be crucial for the antidepressive effect, is also related to the temporary cognitive side effects of ECT. |
| Databáze: | OpenAIRE |
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