A disorder of cortical GABAergic innervation in Alzheimer's disease
| Autor: | Per Wester, Richard F. Cowburn, Anne-Marie O'Carroll, Elisabeth Lofdahl, John Hardy, Bengt Winblad, Amanda J. L. Barton, Peter R. Dodd, Gavin P. Reynolds |
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| Rok vydání: | 1987 |
| Předmět: |
Male
Retrograde Degeneration Hippocampus Hippocampal formation gamma-Aminobutyric acid Neurochemical Alzheimer Disease medicine Humans gamma-Aminobutyric Acid Aged Aged 80 and over Cerebral Cortex General Neuroscience Middle Aged medicine.disease medicine.anatomical_structure Cerebral cortex GABAergic Female Alzheimer's disease Psychology Neuroscience Synaptosomes medicine.drug |
| Zdroj: | Neuroscience Letters. 73:192-196 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(87)90016-4 |
| Popis: | Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder. |
| Databáze: | OpenAIRE |
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