Data on association of mitochondrial heteroplasmy and cardiovascular risk factors: Comparison of samples from Russian and Mexican populations
| Autor: | Alexander N. Orekhov, Igor A. Sobenin, Natalya A. Demakova, Varvara A. Orekhova, Jorge L. Ble Castillo, Alexandra A. Melnichenko, Z.B. Khasanova, Tatiana P. Shkurat, Tatiana V. Kirichenko, Andrey V. Grechko |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA Cell biology BMI body mass index Cardiovascular risk factors Mitochondrial mutations Physiology DBP diastolic blood pressure Disease CVD cardiovascular disease Heteroplasmy lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences 0302 clinical medicine Medicine lcsh:Science (General) Multidisciplinary HDL high-density lipoproteins business.industry SBP systolic blood pressure DBP - Diastolic blood pressure TG triglycerides Atherosclerosis Coronary heart disease Acute cardiovascular disease 030104 developmental biology 030220 oncology & carcinogenesis MI myocardial infarction lcsh:R858-859.7 business BMI - Body mass index LDL low-density lipoproteins lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 18, Iss, Pp 16-21 (2018) Data in Brief |
| ISSN: | 2352-3409 |
| Popis: | Despite the fact that the role of mitochondrial genome mutations in a number of human diseases is widely studied, the effect of mitochondrial heteroplasmy in the development of cardiovascular disease has not been adequately investigated. In this study, we compared the heteroplasmy levels of mtDNA from leukocytes for m.3256C>T, m.3336T>C, m.12315G>A, m.5178C>A, m.13513G>A, m.14459G>A, m.14846G>A, m.15059G>A, m.652insG and m.1555A>G mutations in CVD-free subjects and CVD patients in samples derived from Russian and Mexican populations. It was demonstrated that heteroplasmy level of m.5178C>A was associated with CVD in Russian men, and m.14459G>A – in Russian women. Mitochondrial heteroplasmy level of m.13513G>A and m.652insG were associated with CVD in Mexican men, and only m.652insG– in Mexican women. The levels of heteroplasmy for mitochondrial mutations m.3336T>C, m.5178C>A, m.14459G>A, m.14846G>A and m.1555A>G were significantly higher in CVD-free Mexican men, and for m.3256C>T, m.3336T>C, and m.14459G>A – in CVD-free Mexican women. Keywords: Mitochondrial mutations, Heteroplasmy, Atherosclerosis, Cardiovascular risk factors, Coronary heart disease |
| Databáze: | OpenAIRE |
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