Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial
| Autor: | Paulo Ivo Homem de Bittencourt, Juliano Boufleur Farinha, Helena Trevisan Schroeder, Thiago Rozales Ramis, Winston Boff, Alexandra Ferreira Vieira, Josianne Rodrigues-Krause, Alvaro Reischak-Oliveira, Francesco Pinto Boeno, Carlos Henrique de Lemos Muller, Mauricio Krause, Rodrigo Cauduro Oliveira Macedo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Strength training Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism High-Intensity Interval Training Infusions Subcutaneous Interval training 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Insulin Infusion Systems Internal medicine Diabetes mellitus Post-hoc analysis Internal Medicine Medicine Humans Insulin Glycemic Inflammation Type 1 diabetes business.industry Resistance Training 030229 sport sciences medicine.disease Exercise Therapy Oxidative Stress Diabetes Mellitus Type 1 Female business High-intensity interval training |
| Zdroj: | Journal of diabetes and its complications. 32(12) |
| ISSN: | 1873-460X |
| Popis: | Aims To investigate the effects of high-intensity interval training (HIIT) and/or strength training (ST) on inflammatory, oxidative stress (OS) and glycemic parameters in type 1 diabetes (T1DM) patients. Methods After a 4-week control period, volunteers were randomly assigned to 10-week HIIT, ST or ST + HIIT protocol, performed 3×/week. Blood biochemistry, anthropometric, strength and cardiopulmonary fitness variables were assessed. Outcomes were analyzed via generalized estimating equations (GEE), with Bonferroni post hoc analysis. Results ST, HIIT and ST + HIIT improved glycemic (HbA1c and fasting glucose) and antioxidant parameters (total antioxidant capacity, catalase and superoxide dismutase activities), but not plasma inflammatory (C-reactive protein, TNF-α and IL-10) or OS markers (thiobarbituric acid-reactive substances, 8-hydroxy-2-deoxyguanosine and oxLDL) levels. Noteworthy, interventions reduced soluble receptors for advanced glycation end products levels. However, intracellular heat shock protein 70 content increased only after HIIT. While daily insulin dosage decreased only in the ST + HIIT group, all training models induced anthropometric and functional benefits. Conclusions Similar benefits afforded by ST, HIIT or ST + HIIT in T1DM people are associated with enhanced antioxidant systems and glucose-related parameter, even in a few weeks. From a practical clinical perspective, the performance of ST + HIIT may be advised for additional benefits regarding insulin dosage reduction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect