Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants
Autor: | Gorm Greisen, Gitte Holst Hahn, Simon Trautner, Vibeke R. Eriksen |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Cardiac output Hypothermia Pathology and Laboratory Medicine Diagnostic Radiology Families Heart Rate Hypothermia Induced Ultrasound Imaging Medicine and Health Sciences Prospective Studies Cardiac Output Hypoxia Children Acidosis Asphyxia Neonatorum Asphyxia Neonatorum/blood Multidisciplinary Radiology and Imaging Stroke volume Echocardiography Cardiology Medicine Acidosis Lactic Female medicine.symptom Infants Perfusion Research Article medicine.medical_specialty Imaging Techniques Science Research and Analysis Methods Asphyxia Signs and Symptoms Diagnostic Medicine Internal medicine Heart rate medicine Humans Lactic Acid Acidosis Lactic/blood business.industry Infant Newborn Biology and Life Sciences Cell Biology Lactic Acid/blood medicine.disease Perinatal asphyxia Age Groups People and Places Population Groupings business |
Zdroj: | PLoS ONE, Vol 14, Iss 3, p e0213537 (2019) Eriksen, V R, Trautner, S, Hahn, G H & Greisen, G 2019, ' Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants ', PLoS ONE, vol. 14, no. 3, e0213537 . https://doi.org/10.1371/journal.pone.0213537 PLoS ONE |
ISSN: | 1932-6203 |
Popis: | AIM: We hypothesized that compromised cardiac output in asphyxiated infants may influence on the rate of disappearance of lactate due to insufficient perfusion.METHODS: The study was a prospective, observational study, where infants with perinatal asphyxia who met the criteria for therapeutic hypothermia were included. Cardiac output, stroke volume and heart rate were measured by electrical velocimetry in 15 newborn infants with perinatal asphyxia during the first six hours of active therapeutic hypothermia. Results from routine blood samples were collected retrospectively. Cardiac parameters were also measured in 10 healthy, term infants after caesarian section. Cardiac parameters were compared between the asphyxiated group and the control group prior to and during hypothermia. Rate of disappearance of lactate was correlated to cardiac output in the asphyxiated infants.RESULTS: Cardiac output was stable in the healthy infants from 0.5 to 6 hours postnatally. The infants with perinatal asphyxia had lower cardiac output prior to and during therapeutic hypothermia compared to the control group. Rate of disappearance of lactate was not related to cardiac output.CONCLUSION: An association between disappearance of lactate acidosis and low cardiac output was not confirmed. A low rate of disappearance of lactate may rather be an indicator of organ injury due to asphyxia. |
Databáze: | OpenAIRE |
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