Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants

Autor: Gorm Greisen, Gitte Holst Hahn, Simon Trautner, Vibeke R. Eriksen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Cardiac output
Hypothermia
Pathology and Laboratory Medicine
Diagnostic Radiology
Families
Heart Rate
Hypothermia
Induced
Ultrasound Imaging
Medicine and Health Sciences
Prospective Studies
Cardiac Output
Hypoxia
Children
Acidosis
Asphyxia Neonatorum
Asphyxia Neonatorum/blood
Multidisciplinary
Radiology and Imaging
Stroke volume
Echocardiography
Cardiology
Medicine
Acidosis
Lactic
Female
medicine.symptom
Infants
Perfusion
Research Article
medicine.medical_specialty
Imaging Techniques
Science
Research and Analysis Methods
Asphyxia
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Heart rate
medicine
Humans
Lactic Acid
Acidosis
Lactic/blood
business.industry
Infant
Newborn
Biology and Life Sciences
Cell Biology
Lactic Acid/blood
medicine.disease
Perinatal asphyxia
Age Groups
People and Places
Population Groupings
business
Zdroj: PLoS ONE, Vol 14, Iss 3, p e0213537 (2019)
Eriksen, V R, Trautner, S, Hahn, G H & Greisen, G 2019, ' Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants ', PLoS ONE, vol. 14, no. 3, e0213537 . https://doi.org/10.1371/journal.pone.0213537
PLoS ONE
ISSN: 1932-6203
Popis: AIM: We hypothesized that compromised cardiac output in asphyxiated infants may influence on the rate of disappearance of lactate due to insufficient perfusion.METHODS: The study was a prospective, observational study, where infants with perinatal asphyxia who met the criteria for therapeutic hypothermia were included. Cardiac output, stroke volume and heart rate were measured by electrical velocimetry in 15 newborn infants with perinatal asphyxia during the first six hours of active therapeutic hypothermia. Results from routine blood samples were collected retrospectively. Cardiac parameters were also measured in 10 healthy, term infants after caesarian section. Cardiac parameters were compared between the asphyxiated group and the control group prior to and during hypothermia. Rate of disappearance of lactate was correlated to cardiac output in the asphyxiated infants.RESULTS: Cardiac output was stable in the healthy infants from 0.5 to 6 hours postnatally. The infants with perinatal asphyxia had lower cardiac output prior to and during therapeutic hypothermia compared to the control group. Rate of disappearance of lactate was not related to cardiac output.CONCLUSION: An association between disappearance of lactate acidosis and low cardiac output was not confirmed. A low rate of disappearance of lactate may rather be an indicator of organ injury due to asphyxia.
Databáze: OpenAIRE
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