Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents

Autor:	Dmitri Debabov, Ashley Houchin, Chris Celeri, Eddy Low, Rakesh K. Jain, Bum Tae Kim, Ron Najafi, Satheesh K. Nair, Charles Francavilla, Timothy P. Shiau, Nichole J Alvarez, Ping Xu
Rok vydání:	2009
Předmět:	Clinical Biochemistry Inorganic chemistry Pharmaceutical Science Microbial Sensitivity Tests Sulfonic acid Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Organic chemistry Structure–activity relationship Ammonium Sulfhydryl Compounds Molecular Biology Antibacterial agent chemistry.chemical_classification Aqueous solution Minimum bactericidal concentration Chloramines Organic Chemistry Antimicrobial Quaternary Ammonium Compounds chemistry Anti-Infective Agents Local Molecular Medicine Sulfonic Acids
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:2731-2734
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2009.03.120
Popis:	A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc5e23717325e604cf5fef60704fb16 https://doi.org/10.1016/j.bmcl.2009.03.120 Zobrazit plný text záznamu Full Text from ScienceDirect