Different Potencies of Biosynthetic Human and Purified Porcine Insulin
| Autor: | L. Kerp, F. Enzmann, Schlüter Kj |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Hydrocortisone Swine Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Serum insulin Biology Biochemistry chemistry.chemical_compound Endocrinology Species Specificity Internal medicine medicine Animals Humans Insulin C-Peptide C-peptide Biochemistry (medical) Porcine insulin Biological activity General Medicine Glucose clamp technique chemistry Growth Hormone medicine.drug Hormone |
| Zdroj: | Hormone and Metabolic Research. 15:271-274 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1018693 |
| Popis: | The glucose clamp technique was used to compare the biological activity of purified porcine insulin and Biosynthetic Human Insulin (BHI). An intravenous bolus of 0.1 U/kg BW was injected in eight male volunteers, and the glucose was clamped at baseline values (euglycemic clamp). Serum insulin, serum C-peptide and plasma glucose did not differ between porcine and human insulin. The insulin induced glucose consumption differed significantly (p less than 0.007) between purified porcine insulin (50.5 +/- 5.2 [SEM] g/2h) and Biosynthetic Human Insulin (63.5 +/- 4.5 g/2h). Purified porcine insulin induced a hormonal response with significantly (p less than 0.05) elevated concentrations of serum growth hormone (12.1 +/- 0.25 ng/ml) and serum cortisol (161.4 +/- 28.6 ng/ml), which were not observed following Biosynthetic Human Insulin (serum growth hormone: 2.6 +/- 0.2 ng/ml; serum cortisol: 117.3 +/- 14.8 ng/ml). The data confirm earlier results indicating hormonal and metabolic differences between human and porcine insulin. |
| Databáze: | OpenAIRE |
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