A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol
| Autor: | H M Boss, Henry C. Weinstein, E C de Melker, I A Deijle, Erik J. A. Scherder, B T J van den Berg, Wendy M.J. Bosboom, S. M. van Schaik, R M Van den Berg-Vos |
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| Přispěvatelé: | Clinical Neuropsychology |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Sports medicine SPORTS MEDICINE Physical exercise law.invention Physical medicine and rehabilitation Randomized controlled trial SDG 3 - Good Health and Well-being law Protocol Secondary Prevention Medicine Dementia Aerobic exercise Humans Single-Blind Method Cognitive decline Stroke business.industry Montreal Cognitive Assessment General Medicine medicine.disease Exercise Therapy Neurology Ischemic Attack Transient Physical therapy Female business Cognition Disorders |
| Zdroj: | Boss, H M, Van Schaik, S M, Deijle, I A, de Melker, E C, van den Berg, B M, Scherder, E J A, Bosboom, W M J, Weinstein, H C & van den Berg-Vos, R M 2014, ' A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol ', BMJ Open, vol. 4, no. 12, pp. e007065-e007065 . https://doi.org/10.1136/bmjopen-2014-007065 BMJ Open BMJ Open, 4(12), e007065-e007065. BMJ Publishing Group |
| ISSN: | 2044-6055 |
| Popis: | Introduction Patients with transient ischaemic attack (TIA) or stroke are at risk for cognitive impairment and dementia. Currently, there is no known effective strategy to prevent this cognitive decline. Increasing evidence exists that physical exercise is beneficial for cognitive function. However, in patients with TIA or stroke who are at risk of cognitive impairment and dementia, only a few trials have been conducted. In this study, we aim to investigate whether a physical exercise programme (MoveIT) can prevent cognitive decline in patients in the acute phase after a TIA or minor ischaemic stroke. Methods and analysis A single-blinded randomised controlled trial will be conducted to investigate the effect of an aerobic exercise programme on cognition compared with usual care. 120 adult patients with a TIA or minor ischaemic stroke less than 1 month ago will be randomly allocated to an exercise programme consisting of a 12-week aerobic exercise programme and regular follow-up visits to a specialised physiotherapist during the period of 1 year or to usual care. Outcome measures will be assessed at the baseline, and at the 1-year and 2-year follow-up. The primary outcome is cognitive functioning measured with the Montreal Cognitive Assessment (MoCA) test and with additional neuropsychological tests. Secondary outcomes include maximal exercise capacity, self-reported physical activity and measures of secondary prevention. Ethics and dissemination The study received ethical approval from the VU University Amsterdam Ethics committee (2011/383). The results of this study will be published in peer-reviewed journals and presented at international conferences. We will also disseminate the main results to our participants in a letter. Trial registration number The Nederlands Trial Register NTR3884. |
| Databáze: | OpenAIRE |
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