Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose
Autor: | Qingzhong Mao, Zukang Fu, Si Qin, Chunguang Luan, Rong Liu, Feike Hao, Xinglin Han, Deliang Wang, Jie Xue, Fengjie Zhang |
---|---|
Rok vydání: | 2020 |
Předmět: |
Aging
medicine.medical_specialty Antioxidant 030309 nutrition & dietetics medicine.medical_treatment Yellow rice wine Morris water navigation task Apoptosis lcsh:TX341-641 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology In vivo Antifatigue Internal medicine medicine Wine chemistry.chemical_classification 0303 health sciences Chemistry 04 agricultural and veterinary sciences 040401 food science Lactic acid Cognitive impairment Enzyme Endocrinology Galactose lcsh:Nutrition. Foods and food supply Food Science Behavioural despair test |
Zdroj: | Food Science and Human Wellness, Vol 9, Iss 2, Pp 184-191 (2020) |
ISSN: | 2213-4530 |
Popis: | The present study is focused on investigation of the health protective effect of yellow rice wine (YRW) in mice and the potential underlying mechanism. Symptoms of aging were induced in mice by using D-galactose (D-gal), and different doses of YRW (4, 8, and 12 mL/kg BW) were orally administrated to D-gal-treated mice for a period of six weeks. The in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and liver. Furthermore, a forced swim test showed that moderate intake of YRW (8 mL/kg BW) significantly decreased the duration of immobility, reduced the blood content of urea nitrogen and lactic acid, and increased hepatic glycogen storage. Besides, results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3. The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action. |
Databáze: | OpenAIRE |
Externí odkaz: |