Risk factors and comorbidities in Brazilian patients with orofacial clefts
| Autor: | Raul Hernandes Bortolin, Adriana Augusto de Rezende, Heglayne Pereira Vital da Silva, Marcela Abbott Galvão Ururahy, Maria Edinilma Felinto Brito, Valéria Morgiana Gualberto Duarte Moreira Lima, Thaynnan Thómaz Silva Arruda, Karla Simone Costa de Souza, Gisele Correia Pacheco Leite, André Ducati Luchessi, João Felipe Bezerra |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Cleft Lip Population Comorbidity Risk Assessment Consanguinity Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Quality of life Pregnancy Risk Factors Prevalence medicine Humans General Materials Science 030212 general & internal medicine Young adult Child education education.field_of_study business.industry Smoking Infant Environmental Exposure 030206 dentistry Environmental exposure medicine.disease Cleft Palate lcsh:RK1-715 Maternal Exposure Child Preschool lcsh:Dentistry Etiology Female Risk assessment business Brazil Maternal Age |
| Zdroj: | Brazilian Oral Research, Vol 32, Iss 0 (2018) Brazilian Oral Research v.32 2018 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Brazilian Oral Research, Volume: 32, Article number: e24, Published: 05 APR 2018 |
| ISSN: | 1807-3107 1806-8324 |
| DOI: | 10.1590/1807-3107bor-2018.vol32.0024 |
| Popis: | Considering that environmental risk factors substantially contribute to the etiology of orofacial clefts and that knowledge about the characteristics and comorbidities associated with oral clefts is fundamental to promoting better quality of life, this study aimed to describe the risk factors, main characteristics, and comorbidities of a group of patients with cleft lip and/or cleft palate (CL/P) from Rio Grande do Norte (RN), Brazil. Data were obtained from 173 patients with CL/P using a form from the Brazilian database on Orofacial Clefts. Most patients were male with cleft lip and palate and had a normal size and weight at birth; presented few neonatal intercurrent events; and had anemia and respiratory and cardiovascular diseases as main associated comorbidities. They also required timely surgical rehabilitation and multidisciplinary care to stimulate their neuropsychomotor development. In addition, a high frequency of familial recurrence and of parental consanguinity was evidenced in the studied population, especially for the cleft lip and cleft palate type. Other relevant findings were the considerable maternal exposure to alcohol, infections, smoking, and hypertension, as well as low supplementation with vitamins and minerals and deliberate consumption of analgesics, antibiotics, and antihypertensives during pregnancy. Characterization of the CL/P patient profile is essential for the planning of health services and integration among the health professionals involved in the diagnosis and treatment of these malformations. Our results reinforce the need for additional research to confirm the association between environmental factors and the development of orofacial clefts. |
| Databáze: | OpenAIRE |
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