Detection and clinical significance of Ba2+- and Sr2+-dependent antiprothrombin antibodies in patients with systemic lupus erythematosus and antiphospholipid syndrome
| Autor: | T Sanaka, T Teramoto, J. Matsuda |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
0301 basic medicine
Adult Male Cations Divalent Phosphatidylserines 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Rheumatology Antiphospholipid syndrome Medicine Humans Lupus Erythematosus Systemic In patient Clinical significance Autoantibodies Lupus anticoagulant business.industry Middle Aged medicine.disease Antiphospholipid Syndrome Antiprothrombin antibodies 030104 developmental biology Barium Strontium Immunology Anticardiolipin antibodies Female Prothrombin business |
| Zdroj: | Lupus. 12(2) |
| ISSN: | 0961-2033 |
| Popis: | We conducted this study to confirm whether or not Ca2+-dependent antiprothrombinantibody (aPT) in patients’sera with systemic lupuserythematosusand=or primary antiphospholipidsyndromewould react to prothrombin=phosphatidylserinein the presenceof Sr2+, Mn2+ or Ba2+, or divalentmetal ions like Ca2+, utilizingELISA, and to analyze the clinical significance of these metal-dependentaPT. We found the presence of Ba2+- and Sr2+-dependent IgG, IgM and IgA-aPT in up to 65% of patients negative for Ca2+-dependent IgG-, IgM and IgA-aPT. Maximally 69% of them were complicated by antiphospholipidsyndrome-relatedsymptoms. These data suggest that the measurementof Ba2+- and Sr2+- along with Ca2+-dependentaPT may become a clinicallyuseful tool to correctly detect patients with antiphospholipid-related complications. However, further study is needed to clarify the clinicopathologicaldifferences among these aPTs in the future. |
| Databáze: | OpenAIRE |
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