Cohort study of plasma natriuretic peptides for identifying left ventricular systolic dysfunction in primary care
| Autor: | John J.V. McMurray, L Caruana, Steven Goldthorp, Samuel J. McClure, Andrew Davie |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease medicine.drug_class General Practice Population Myocardial Infarction Sensitivity and Specificity Cohort Studies Ventricular Dysfunction Left Atrial natriuretic peptide Internal medicine medicine Natriuretic peptide Humans cardiovascular diseases Myocardial infarction Systole education Aged General Environmental Science Aged 80 and over education.field_of_study business.industry General Engineering General Medicine Middle Aged medicine.disease Brain natriuretic peptide ROC Curve Echocardiography Heart failure cardiovascular system Cardiology General Earth and Planetary Sciences Female Family Practice business Atrial Natriuretic Factor |
| Zdroj: | BMJ. 317:516-519 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.317.7157.516 |
| Popis: | Objectives : To determine whether blood natriuretic peptide concentrations are helpful in identifying or excluding left ventricular systolic dysfunction in stable survivors of acute myocardial infarction. Design : Comparison of blood natriuretic peptide concentrations with echocardiographic assessment of left ventricular systolic function in a general practice population. Setting : Practices in Western District of Glasgow audit group. Subjects : 134 long term survivors of myocardial infarction recalled for echocardiography as part of a primary care secondary prevention audit. Main outcome measures : Area under the receiver operating curve for brain natriuretic peptide and N-terminal atrial natriuretic peptide. Results : Brain natriuretic peptide was of some diagnostic utility in identifying the minority of subjects with severe left ventricular dysfunction (area under curve=0.73) but was unable to discriminate between patients with moderately severe dysfunction and those with preserved left ventricular function (area under curve for moderate or severe dysfunction=0.54). The corresponding values forN-terminal atrial natriuretic peptide for severe and moderate or severe dysfunction were 0.55 and 0.56 respectively. Conclusions : Blood natriuretic peptide concentrations are not useful in identifying important left ventricular systolic dysfunction in stable survivors of myocardial infarction. |
| Databáze: | OpenAIRE |
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