Maternal Stress Produces Learning Deficits Associated with Impairment of NMDA Receptor-Mediated Synaptic Plasticity
| Autor: | Sukwoo Choi, Sooyoung Chung, Eunjoo Kim, Gi Hoon Son, Kun Ho Lee, Kyungjin Kim, Jihoon Jo, Hyun Koo Kim, Changmee Kim, Chang-Joong Lee, Hyun Kim, Dongho Geum |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Restraint Physical Offspring Long-Term Potentiation Hippocampus Hippocampal formation Receptors N-Methyl-D-Aspartate Synaptic Transmission Mice Maternal stress Organ Culture Techniques Pregnancy Animals Memory Disorders Mice Inbred ICR Neuronal Plasticity Learning Disabilities General Neuroscience Long-term potentiation Articles Electrophysiology Animals Newborn nervous system Prenatal Exposure Delayed Effects Synaptic plasticity NMDA receptor Female Psychology Neuroscience Stress Psychological |
| Zdroj: | The Journal of Neuroscience. 26:3309-3318 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.3850-05.2006 |
| Popis: | Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects the brain function of offspring when they are adult remains primarily unknown. In the present work, chronic immobilization stress to pregnant mice affected fetal growth and development. When pups born from stressed mice were reared to adulthood in an environment identical to that of nonstressed controls, several physiological parameters were essentially unaltered. However, spatial learning and memory was significantly impaired in the maternally stressed offspring in adulthood. Furthermore, electrophysiological examination revealed a significant reduction in NMDA receptor-mediated long-term potentiation in the CA1 area of hippocampal slices. Subsequent biochemical analysis demonstrated a substantial decrease in NR1 and NR2B subunits of the NMDA receptor in synapses of the hippocampus, and the interaction between these two subunits appeared to be reduced. These results suggest that prolonged maternal stress leads to long-lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. |
| Databáze: | OpenAIRE |
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