High Precision DNA Modification Analysis of HCG9 in Major Psychosis
| Autor: | Sun Chong Wang, Gabriel Oh, Sasha Ebrahimi, Mrinal Pal, Aiping Zhang, Tarang Khare, Arturas Petronis, Zachary Kaminsky |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Psychosis Bipolar Disorder padlock probes brain Bisulfite sequencing Prefrontal Cortex Biology Epigenesis Genetic chemistry.chemical_compound medicine Cadaver Humans Epigenetics Bipolar disorder Gene Aged Genetics Aged 80 and over epigenetics Regular Article DNA Sequence Analysis DNA DNA Methylation Middle Aged medicine.disease 3. Good health schizophrenia Psychiatry and Mental health CpG site chemistry Psychotic Disorders Schizophrenia Case-Control Studies bisulfite sequencing Female RNA Long Noncoding |
| Zdroj: | Schizophrenia Bulletin |
| ISSN: | 1745-1701 0586-7614 |
| Popis: | New epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis. In this study, we applied padlock probe-based ultra-deep bisulfite sequencing for fine mapping of modified cytosines of the HLA complex group 9 (nonprotein coding) gene in the postmortem brains of individuals affected with schizophrenia or bipolar disorder and unaffected controls. Significant differences between patients and controls were detected in both CpG and CpH modifications. In addition, we identified epigenetic age effects, DNA modification differences between sense and anti-sense strands, and demonstrated how DNA modification data can be used in clustering of patient populations. Our findings revealed new epigenetic complexities but also highlighted the potential of DNA modification approaches in the search of heterogeneous causes of major psychiatric disease. |
| Databáze: | OpenAIRE |
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