Extremely High Ferritinemia Associated with Haemophagocytic Lympho Histiocytosis (HLH)
| Autor: | Alka Girotra, Jyoti chakraverty, Neelima Verma, Manish Chugh, Pankaj Baweja, Leena Chatterjee |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
medicine.diagnostic_test business.industry fungi Clinical Biochemistry Acute-phase protein Case Report medicine.disease Sputum culture Sepsis Bone marrow examination 03 medical and health sciences Histiocytosis 0302 clinical medicine 030220 oncology & carcinogenesis Macrophage activation syndrome Immunology medicine Hemophagocytosis business Macrophage proliferation |
| Zdroj: | Indian Journal of Clinical Biochemistry. 32:117-120 |
| ISSN: | 0974-0422 0970-1915 |
| Popis: | Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc. A case study in our hospital showed extremely high ferritin values along with low hemoglobin, elevated LDH and triglycerides with positive MRSA in sputum culture and macrophage proliferation and hemophagocytosis in the bone marrow examination. Patient showed definite inverse relation with steroid therapy and serum ferritin levels. |
| Databáze: | OpenAIRE |
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