Drug rash with eosinophilia and systemic symptoms and graft-versus-host disease developing sequentially in a patient
| Autor: | K M T Watson, J. Natkunarajah, Salvador J. Diaz-Cano, Daniel Creamer, Ghulam J. Mufti, A.W.P. Du Vivier |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Congenital cytomegalovirus infection Cytomegalovirus Graft vs Host Disease Dermatology Disease immune system diseases Eosinophilia Drug rash Humans Medicine Drug reaction Lymphokines integumentary system business.industry Lymphoma Non-Hodgkin Hematopoietic Stem Cell Transplantation Middle Aged medicine.disease Anti-Bacterial Agents Graft-versus-host disease surgical procedures operative Cytomegalovirus Infections Immunology Virus Activation Drug Eruptions medicine.symptom Gram-Negative Bacterial Infections business |
| DOI: | 10.6084/m9.figshare.97444.v1 |
| Popis: | Summary We describe a case of drug rash with eosinophilia and systemic symptoms (DRESS) and graft-versus-host disease (GvHD) developing sequentially in a patient displaying reactivation of CMV. We discuss the possibility that similar pathogenic mechanisms may be involved in the development of DRESS and GvHD. Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe acute drug reaction characterized by a polymorphic skin eruption associated with fever, eosinophilia, lymphadenopathy and multiorgan involvement. 1 The development of DRESS has been associated with reactivation of herpesviruses. 2,3 This relationship is similar to the relationship between herpesvirus reactivation and the development of graftversus-host disease (GvHD). 4 We report a case of DRESS and GvHD developing sequentially in a patient displaying reactivation of cytomegalovirus (CMV). |
| Databáze: | OpenAIRE |
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