Therapeutic efficacy of Nano-formulation of lactoperoxidase and lactoferrin via promoting immunomodulatory and apoptotic effects

Autor:	Esmail M, El-Fakharany, Mahmoud, Ashry, Abd-Elaleem H, Abd-Elaleem, Mahmoud H, Romeih, Fatma Adly, Morsy, Reem A, Shaban, Khaled G, Abdel-Wahhab
Rok vydání:	2022
Předmět:	Superoxide Dismutase Tumor Necrosis Factor-alpha Immunity Apoptosis Mammary Neoplasms Animal General Medicine Biochemistry Rats Lactoferrin Structural Biology Creatinine MCF-7 Cells Animals Humans Nanoparticles Urea Female Lactoperoxidase Molecular Biology Triglycerides
Zdroj:	International Journal of Biological Macromolecules. 220:43-55
ISSN:	0141-8130
Popis:	This study identifies promising potential of a novel and safer nanocombination of bovine milk lactoperoxidase (LPO) and lactoferrin (LF) to target breast cancer in vitro and in adult female albino rat model. Favorable selective anticancer effects of the prepared nanocombination were observed, in a dose-dependent manner, against both MCF-7 and MDA cell lines, sparing normal HFB-4 cells. The administration of LPO + LFNPs markedly improved the induced-breast cancer disorders, prolonged survival and reduced the values of serum TNF-α, IL1β, CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb7b4f7db2e1da134dc994659d2fc26 https://doi.org/10.1016/j.ijbiomac.2022.08.067 Zobrazit plný text záznamu Full Text from ScienceDirect