Impact of endometrioma resection on eutopic endometrium metabolite contents: Noninvasive evaluation of endometrium receptivity
| Autor: | Aynur Erşahin, Suphan Ersahin, Duygu Kara Bozkurt, Mustafa Acet, Selçuk İlhan, Tuba Acet, Onder Celik, Yasemin Yavuz |
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| Přispěvatelé: | Erşahin, Süphan |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Magnetic Resonance Spectroscopy Metabolite Endometriosis Receptivity Urology Endometrium Creatine Benign Ovarian Cyst Choline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Medicine Cyst Endometrioma Lactic Acid Laparoscopy Spectroscopy Gynecology Aspartic Acid 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Obstetrics and Gynecology medicine.disease Ovarian Cysts 030104 developmental biology medicine.anatomical_structure chemistry Female business Eutopic Endometrium |
| Popis: | WOS: 000400087600017 PubMed ID: 27678098 The aim of this study was to determine whether endometrioma resection alters most commonly defined endometrial metabolites, lactate (Lac), N-acetylaspartate (NAA), creatine 1 (Cr1), creatine 2 (Cr2), and choline (Cho) during the window of implantation. Twenty patients with uni- or bilateral endometrioma and 7 patients having nonendometriotic benign ovarian cyst were included. Midluteal phase magnetic resonance spectroscopy analysis of eutopic endometrium was performed before surgery. Second spectrum of endometrium was obtained 3 to 5 months after laparoscopic endometrioma resection. Pre- and postoperative endometrial peaks of Lac, NAA, Cr, and Cho were measured in units and denominated in parts per million (ppm). Compared to preoperative peak values, significantly decreased NAA, Lac, and Cr1 signals were noted in patients undergoing endometrioma surgery. Nearly 5-fold decline in the NAA signal occurred after endometrioma surgery (1.94 +/- 3.24 vs 0.37 +/- 0.55). Likewise, 2.5-fold decline in Lac signals was noted after endometrioma resection (2.81 +/- 2.64 vs 1.06 +/- 1.88). Both uni- and bilateral endometrioma affected endometrium signals the same. The peak intensity of Cho, Cr1, Cr2, NAA, and Lac did not alter significantly after nonendometriotic cyst surgery. Endometrioma surgery straightens endometrial NAA, Lac, and Cr1 peaks, suggesting improvement in endometrial receptivity. |
| Databáze: | OpenAIRE |
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