Prenatal mercury exposure and child neurodevelopment outcomes at 18 months: Results from the Mediterranean PHIME cohort

Autor: David Neubauer, Jana Kodrič, Igor Prpić, Anica Casetta, Francesca Sammartano, D’Anna Little, Fabio Barbone, Luca Ronfani, Valentina Rosolen, Darja Mazej, Luigi Castriotta, Staša Stropnik, Oleg Petrović, Joško Osredkar, Maura Bin, Ana Miklavčič Višnjevec, Francesca Valent, Maria Parpinel, Inge Vlašić-Cicvarić, Mladen Krsnik, Katia Sofianou, Zdravko Špirić, Milena Horvat, Liza Vecchi Brumatti, Janja Snoj Tratnik, Marika Mariuz
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Developmental motor scales
010501 environmental sciences
BIOTEHNIČKE ZNANOSTI. Interdisciplinarne biotehničke znanosti
Logistic regression
01 natural sciences
Bayley Scales of Infant Development
0302 clinical medicine
Child Development
Pregnancy
INTERDISCIPLINARY AREAS OF KNOWLEDGE. Integrative Bioethics (Natural
Technical
Biomedical and Healthcare
Social and Humanistic Sciences)
030212 general & internal medicine
INTERDISCIPLINARY AREAS OF KNOWLEDGE. Biotechnology in Biomedicine (natural science
biomedicine and healthcare
bioethics area
Obstetrics
Child neurodevelopment
Bayley scales of infant and toddler development
Cohort study
Fish
Mercury
Public Health
Environmental and Occupational Health
Environmental exposure
Prenatal Exposure Delayed Effects
Cohort
Female
Public Health
TEHNIČKE ZNANOSTI. Interdisciplinarne tehničke znanosti
Adult
medicine.medical_specialty
03 medical and health sciences
Young Adult
INTERDISCIPLINARNA PODRUČJA ZNANOSTI. Integrativna bioetika (prirodne
tehničke
biomedicina i zdravstvo
biotehničke
društvene
humanističke znanosti)
medicine
Humans
Toddler
development
0105 earth and related environmental sciences
Mercury
Fish
Child neurodevelopment
Bayley scales of infant and toddler
development
Developmental motor scales
Cohort study
TECHNICAL SCIENCES. Interdisciplinary Technical Sciences
business.industry
Environmental and Occupational Health
Infant
Odds ratio
Environmental Exposure
medicine.disease
BIOTECHNICAL SCIENCES. Interdisciplinary Technical Sciences
Bayley scales of infant and toddler
Neurodevelopmental Disorders
INTERDISCIPLINARNA PODRUČJA ZNANOSTI. Biotehnologija u biomedicini (prirodno područje
biomedicina i zdravstvo
biotehničko područje)
business
Zdroj: International journal of hygiene and environmental health
Volume 222
Issue 1
ISSN: 1438-4639
Popis: Introduction Neurotoxicity due to acute prenatal exposure to high-dose of mercury (Hg) is well documented. However, the effect of prenatal exposure to low Hg levels on child neurodevelopment and the question about “safety” of fish-eating during pregnancy remain controversial. International comparisons of Hg concentrations in mother-child biological samples and neurodevelopmental scores embedded in birth cohort studies may provide useful evidence to explore this issue. Materials and methods The Mediterranean (Italy, Slovenia, Croatia, and Greece) cohort study included 1308 mother-child pairs enrolled in the Public Health Impact of long-term, low-level, Mixed Element exposure in a susceptible population EU Sixth Framework Programme (PHIME). Maternal hair and venous blood, cord blood and breast milk samples were collected, and total Hg (THg) levels were measured. Demographic and socioeconomic information, lifestyles and nutritional habits were collected through questionnaires at different phases of follow-up. Children at 18 months of age underwent neurodevelopmental testing using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Multivariate linear and logistic regressions were performed, for each country, to assess the association between THg and BSID-III scores, obtaining adjusted β coefficients and odds ratios (ORs). These values were used to conduct a meta-analysis, to explore possible heterogeneity among countries and to obtain combined estimates of the association between THg exposure and BSID-III scores. Results Median THg (ng/g) was: 704 in maternal hair, 2.4 in maternal blood, 3.6 in cord blood, and 0.6 in breast milk. THg concentrations were highest in Greece and lowest in Slovenia. BSID-III neurodevelopmental scores were higher in Croatia and Slovenia. The meta-analysis of multivariate linear models found an overall positive association between language composite score and receptive communication scaled score and increasing THg in maternal hair (n = 1086; β = 0.55; 95%CI: 0.05–1.05 and n = 1075; β = 0.12; 95%CI: 0.02–0.22, respectively). The meta-analysis of logistic regression models showed that the overall adjusted OR between THg in cord blood and suboptimal gross motor score was borderline significant (n = 882; OR = 1.03; 95%CI: 1.00–1.07). Heterogeneity was found across the four sub-cohorts for language composite score in maternal blood, and for fine motor scaled score in cord blood and breast milk. Language composite score and THg concentrations in maternal venous blood were positively related (n = 58; β = 4.29; CI95% (−0.02, 8.60)) in Croatia and an increase of 1 ng/g of THg in maternal venous blood was associated with a reduced risk for children to fall in the lowest quintile of language score by 31% (n = 58; OR = 0.69; CI 95%: 0.37, 1.01). The comparison of β coefficients obtained by multiple linear regression model showed an inverse association between fine motor score and THg concentrations in cord blood for Croatia (n = 54; β = −0.53; CI 95%: −1.10, 0.04) and Slovenia (n = 225; β = −0.25; CI 95%: −0.49, −0.01). In Slovenia THg level in breast milk was associated with suboptimal fine motor performance (n = 195; OR = 5.25; CI 95%: 1.36, 21.10). Conclusions This study showed an inverse relation between THg levels and developmental motor scores at 18 months, although the evidence was weak and partially internally and externally inconsistent. No evidence of detrimental effects of THg was found for cognitive and language outcomes at these concentrations and age.
Databáze: OpenAIRE
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