A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic
| Autor: | Stephanie Thomas, Zahra Qamar, Daniel Frisch, Baskaran Sundaram, Ross Summer, Joeseph DeSimone, Gautam George, Corbin Pomeranz, Aishwarya Gulati |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Middle East respiratory syndrome coronavirus viruses Pneumonia Viral Context (language use) 030204 cardiovascular system & hematology Severe Acute Respiratory Syndrome medicine.disease_cause Article MERS-CoV Betacoronavirus 03 medical and health sciences 0302 clinical medicine Pandemic Humans Medicine 030212 general & internal medicine Intensive care medicine Pandemics Coronavirus Novel coronavirus biology SARS-CoV-2 business.industry COVID-19 virus diseases Outbreak SARS-CoV General Medicine medicine.disease biology.organism_classification respiratory tract diseases Pneumonia Severe acute respiratory syndrome-related coronavirus Middle East Respiratory Syndrome Coronavirus Coronavirus Infections business Encephalitis |
| Zdroj: | The American Journal of the Medical Sciences |
| ISSN: | 0002-9629 |
| Popis: | Since December 2019, the global pandemic caused by the highly infectious novel coronavirus 2019-nCoV (COVID-19) has been rapidly spreading. As of April 2020, the outbreak has spread to over 210 countries, with over 2,400,000 confirmed cases and over 170,000 deaths [1]. COVID-19 causes a severe pneumonia characterized by fever, cough, and shortness of breath. Similar coronavirus outbreaks have occurred in the past causing severe pneumonia like COVID-19, most recently, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). However, over time, SARS-CoV and MERS-CoV were shown to cause extra-pulmonary signs and symptoms including hepatitis, acute renal failure, encephalitis, myositis, and gastroenteritis. Similarly, sporadic reports of COVID-19 related extrapulmonary manifestations emerge. Unfortunately, there is no comprehensive summary of the multi-organ manifestations of COVID-19, making it difficult for clinicians to quickly educate themselves about this highly contagious and deadly pathogen. What's more, is that SARS-CoV and MERS-CoV are the closest humanity has come to combating something similar to COVID-19, however, there exists no comparison between the manifestations of any of these novel coronaviruses. In this review, we summarize the current knowledge of the manifestations of the novel coronaviruses SARS-CoV, MERS-CoV, and COVID-19, with a particular focus on the latter, and highlight their differences and similarities. |
| Databáze: | OpenAIRE |
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