The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function
| Autor: | Richard D. Cummings, Marcelo Dias-Baruffi, Birk Evavold, Nourine A. Kamili, Connie M. Arthur, Brian S. Robinson, Caleb S. Stowell, Ethan Roback, Mary L. Vallecillo-Zúniga, Pam M. Van Ry, Sean R. Stowell |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Neutrophils Phagocytosis Galectins Immunology Inflammation Review Biology 03 medical and health sciences 0302 clinical medicine Immunity medicine Immunology and Allergy Animals Humans Pathogen Galectin IMUNIDADE galectin glycoscience neutrophil Chemotaxis Extravasation Immunity Innate 030104 developmental biology inflammation glycans medicine.symptom lcsh:RC581-607 Function (biology) 030215 immunology |
| Zdroj: | Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1664-3224 |
| Popis: | Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, which requires efficient extravasation, activation, chemotaxis, phagocytosis, and eventual killing of potential microbial pathogens. Following pathogen elimination, neutrophils must be eliminated to prevent additional host injury and subsequent exacerbation of the inflammatory response. Galectins, expressed in nearly every tissue and regulated by unique sensitivity to oxidative and proteolytic inactivation, appear to influence nearly every aspect of neutrophil function. In this review, we will examine the impact of galectins on neutrophils, with a particular focus on the unique biochemical traits that allow galectin family members to spatially and temporally regulate neutrophil function. |
| Databáze: | OpenAIRE |
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