'All pigs are equal' Does the background data from juvenile Göttingen minipigs support this?
| Autor: | Sandra De Jonghe, Edward Marsden, Maria Desmidt, Laure Penard, Marjolein van Heerden, Bianca Feyen, Pierluigi Fant, Graham Bailey, Sien Maki Mousa |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Pathology Aging 040301 veterinary sciences Swine Economic shortage Pilot Projects Toxicology 030226 pharmacology & pharmacy 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Species Specificity Control data Toxicity Tests medicine Juvenile Animals Intensive care medicine Clinical pathology business.industry Background data 04 agricultural and veterinary sciences Normal variation Animals Newborn Organ Specificity Models Animal Swine Miniature Female business |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 64 |
| ISSN: | 1873-1708 |
| Popis: | For pediatric indications requiring juvenile toxicity testing, the rat is the preferred species. However, for some drugs it might not be an appropriate model or regulatory agencies may also request a non-rodent species. Due to the relatively recent use of Gottingen minipigs, little background data are available. This shortage of historical data can raise concerns with respect to interpretation, thus potentially discouraging investigators. This article presents background data from 82 piglets collected at different ages. The data described show the normal variations and changes which are important in the interpretations of these studies. Age-related changes were observed for several cardiac and clinical pathology parameters and in the haematopoietic tissues. Therefore, all pigs were not considered equal. It can be concluded that these data can be used as guidance, to support the concurrent study control data but cannot completely replace them. |
| Databáze: | OpenAIRE |
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