Crystal and Particle Engineering Strategies for Improving Powder Compression and Flow Properties to Enable Continuous Tablet Manufacturing by Direct Compression
| Autor: | Sayantan Chattoraj, Changquan Calvin Sun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Process (engineering)
Computer science Drug Compounding media_common.quotation_subject Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Quality by Design Excipients Crystal (programming language) 03 medical and health sciences 0302 clinical medicine Pressure Quality (business) Particle Size Process engineering media_common Flexibility (engineering) business.industry 021001 nanoscience & nanotechnology Compression (physics) SCALE-UP Particle Powders Crystallization 0210 nano-technology business Tablets |
| Zdroj: | Journal of Pharmaceutical Sciences. 107:968-974 |
| ISSN: | 0022-3549 |
| DOI: | 10.1016/j.xphs.2017.11.023 |
| Popis: | Continuous manufacturing of tablets has many advantages, including batch size flexibility, demand-adaptive scale up or scale down, consistent product quality, small operational foot print, and increased manufacturing efficiency. Simplicity makes direct compression the most suitable process for continuous tablet manufacturing. However, deficiencies in powder flow and compression of active pharmaceutical ingredients (APIs) limit the range of drug loading that can routinely be considered for direct compression. For the widespread adoption of continuous direct compression, effective API engineering strategies to address power flow and compression problems are needed. Appropriate implementation of these strategies would facilitate the design of high-quality robust drug products, as stipulated by the Quality-by-Design framework. Here, several crystal and particle engineering strategies for improving powder flow and compression properties are summarized. The focus is on the underlying materials science, which is the foundation for effective API engineering to enable successful continuous manufacturing by the direct compression process. |
| Databáze: | OpenAIRE |
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