Regulation of Hedgehog signaling by ubiquitination

Autor:	Elaine Y. C. Hsia, Yirui Gui, Xiaoyan Zheng
Rok vydání:	2015
Předmět:	Ecology Biology Proteomics Bioinformatics Article Hedgehog signaling pathway Cell biology Ubiquitin Genetics biology.protein Signal transduction Hedgehog Developmental biology Ecology Evolution Behavior and Systematics Function (biology) Biotechnology Adult stem cell
Zdroj:	Frontiers in Biology. 10:203-220
ISSN:	1674-7992 1674-7984
DOI:	10.1007/s11515-015-1343-5
Popis:	The Hedgehog (Hh) signaling pathway plays crucial roles both in embryonic development and in adult stem cell function. The timing, duration and location of Hh signaling activity need to be tightly controlled. Abnormalities of Hh signal transduction lead to birth defects or malignant tumors. Recent data point to ubiquitination-related posttranslational modifications of several key Hh pathway components as an important mechanism of regulation of the Hh pathway. Here we review how ubiquitination regulates the localization, stability and activity of the key Hh signaling components.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cafaa7b7acd466f8f7e44a441691836 https://doi.org/10.1007/s11515-015-1343-5 Zobrazit plný text záznamu Full text from SpringerLink