Determining heterocyclic aromatic amines in aqueous samples: A novel dispersive liquid-liquid micro-extraction method based on solidification of floating organic drop and ultrasound assisted back extraction followed by UPLC-MS/MS
| Autor: | Mario Reta, Cristian Bazán, Soledad Cerutti, Romina Canales, María Guiñez |
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| Rok vydání: | 2017 |
| Předmět: |
Analyte
DISPERSIVE LIQUID-LIQUID MICROEXTRACTION Analytical chemistry 02 engineering and technology Mass spectrometry 01 natural sciences Analytical Chemistry FLOATING ORGANIC DROP Detection limit ULTRASOUND ASSISTED BACK EXTRACTION Chromatography Aqueous solution Chemistry Drop (liquid) Otras Ciencias Químicas 010401 analytical chemistry Ciencias Químicas Water extraction Repeatability 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent UPLC-MS/MS HETEROCYCLIC AROMATIC AMINES 0210 nano-technology CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Talanta. 174 |
| ISSN: | 1873-3573 |
| Popis: | A novel dispersive liquid-liquid microextraction based on solidification of floating organic droplet combined with ultrasound assisted back extraction for the determination of four heterocyclic aromatic amines in natural water samples prior ultra high-performance liquid chromatography-tandem mass spectrometry was developed. The analytes were extracted from the water samples by a dispersive liquid-liquid microextraction procedure based on solidification of floating organic drop, which was performed by a mixture composed by a less dense than water extraction solvent, 1-undecanol, and a dispersive solvent, methanol. After that, a novel ultrasound assisted back extraction step was performed in order to make the clean-up/enrichment procedure compatible with the detection requirements. Under optimum conditions, linearity ranged from 2.2 to 50 ng mL−1, with enrichment factors from 130 to 136-folds. Thus limits of detection between 0.7 and 2.9 ng mL−1 were obtained. Precision of the method was evaluated in terms of repeatability, relative standard deviations varied from 4.3% to 6.7%. Relative recoveries ranged from 92% to 106% for all analytes. The satisfactory performance demonstrated that the proposed methodology has a strong potential for application in the multi-residue analysis of heterocyclic aromatic amines present in complex environmental matrices. Fil: Canales, Maria Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Guiñez, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Bazan, Cristian Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Reta, Mario Roberto. Universidad Nacional de La Plata; Argentina Fil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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