A Radio Frequency Electric Current Enhances Antibiotic Efficacy against Bacterial Biofilms
| Autor: | M. de Belém Rodrigues, E. Freye, W. J. Ellison, F. Pedarros-Caubet, J. M. Moreau, R. Caubet, M. Chu |
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| Přispěvatelé: | Laboratoire de l'intégration, du matériau au système (IMS), Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2004 |
| Předmět: |
Radio Waves
Colony Count Microbial Oxytetracycline biofilm Microbiology 03 medical and health sciences Electricity antibiotic Escherichia coli medicine Pharmacology (medical) Mechanisms of Action: Physiological Effects ComputingMilieux_MISCELLANEOUS 030304 developmental biology Antibacterial agent Pharmacology 0303 health sciences biology 030306 microbiology Direct current Biofilm Biofilm matrix radio frequency current biology.organism_classification [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Anti-Bacterial Agents Solutions Infectious Diseases Biofilms Gentamicin Radio frequency Gentamicins Electric current Bacteria medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2004, 48 (12), pp.4662-4664. ⟨10.1128/AAC.48.12.4662-4664.2004⟩ |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Bacterial biofilms are notably resistant to antibiotic prophylaxis. The concentration of antibiotic necessary to significantly reduce the number of bacteria in the biofilm matrix can be several hundred times the MIC for the same bacteria in a planktonic phase. It has been observed that the addition of a weak continuous direct electric current to the liquid surrounding the biofilm can dramatically increase the efficacy of the antibiotic. This phenomenon, known as the bioelectric effect, has only been partially elucidated, and it is not certain that the electrical parameters are optimal. We confirm here the bioelectric effect for Escherichia coli biofilms treated with gentamicin and with oxytetracycline, and we report a new bioelectric effect with a radio frequency alternating electric current (10 MHz) instead of the usual direct current. None of the proposed explanations (transport of ions within the biofilm, production of additional biocides by electrolysis, etc.) of the direct current bioelectric effect are applicable to the radio frequency bioelectric effect. We suggest that this new phenomenon may be due to a specific action of the radio frequency electromagnetic field upon the polar parts of the molecules forming the biofilm matrix. |
| Databáze: | OpenAIRE |
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