Engineering Heart Morphogenesis
| Autor: | Ying Zheng, Jennifer Davis, Danny El-Nachef, Nisa P. Williams, Deok Ho Kim, Ivan Batalov, Christian Mandrycky, Cole A. DeForest, Bernadette S. de Bakker, Kelly R. Stevens, Nathan J. Sniadecki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Heart morphogenesis Computer science Process (engineering) heart tube looping organogenesis Bioengineering 02 engineering and technology Article 03 medical and health sciences Mechanobiology Tissue engineering stem cells Morphogenesis Animals Humans Cardiac morphogenesis Heart mechanobiology Stem Cell Research 021001 nanoscience & nanotechnology Heart tube 030104 developmental biology tissue engineering 0210 nano-technology Neuroscience Stem cell biology Signal Transduction Stem Cell Transplantation Biotechnology biomaterials |
| Zdroj: | Trends Biotechnol |
| ISSN: | 0167-7799 |
| Popis: | Recent advances in stem cell biology and tissue engineering have laid the groundwork for building complex tissues in a dish. We propose that these technologies are ready for a new challenge: recapitulating cardiac morphogenesis in vitro. In development, the heart transforms from a simple linear tube to a four-chambered organ through a complex process called looping. In this perspective, we re-examine heart tube looping through the lens of an engineer and argue that the linear heart tube is an advantageous starting point for tissue engineering. We summarize the structures, signaling pathways, and stresses in the looping heart, and evaluate approaches that could be used to build a linear heart tube and guide it through the process of looping. |
| Databáze: | OpenAIRE |
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