Epidemiological information regarding the periodic epidemics of influenza C virus in Japan (1996-2013) and the seroprevalence of antibodies to different antigenic groups
| Autor: | Tatsuya Ikeda, Chieko Abiko, Yoko Matsuzaki, Noriko Katsushima, Tsutomu Itagaki, Kanetsu Sugawara, Fumio Katsushima, Yoko Aoki, Yasushi Muraki, Hidekazu Nishimura, Yoshitaka Shimotai, Yuriko Katsushima, Katsumi Mizuta, Seiji Hongo |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Influenzavirus C Virus Cultivation Adolescent Molecular Sequence Data Antibodies Viral H5N1 genetic structure Antigenic drift Young Adult Japan Virology Influenza Human Seroprevalence Outpatient clinic Humans Selection Genetic Child Epidemics Antigens Viral Hemagglutination assay biology Hemagglutinin esterase Infant Newborn Infant Sequence Analysis DNA Hemagglutination Inhibition Tests Middle Aged Infectious Diseases Child Preschool Immunology biology.protein RNA Viral Female Antibody Influenza C Virus |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 61(1) |
| ISSN: | 1873-5967 |
| Popis: | Background Although influenza C virus is widely distributed throughout the world, epidemiological information, based on long-term surveillance, has not yet been acquired. Objectives To clarify the epidemiological features of influenza C virus infection, and to examine whether the prevalence of the antibodies against the influenza C virus is associated with the epidemics. Study design Between 1996 and 2013, 36,973 respiratory specimens were collected from two pediatric outpatient clinics in Yamagata, Japan. The specimens were examined for the presence of influenza C virus using cell culture methods. Isolated viruses were antigenically analyzed. The differences in seropositivity, with respect to the different antigenic groups, were examined using serum samples collected in 2001 and 2011 by a hemagglutination inhibition assay. Results Influenza C viruses were isolated from 190 specimens during an 18-year period. Most influenza C viruses were isolated from winter to early summer in even-numbered years, and the frequency of virus isolation per year ranged from 0.43% to 1.73%. An antigenic analysis revealed that the dominant antigenic groups were the C/Yamagata/26/81 from 1996 to 2000, the C/Kanagawa/1/76 in 2002 and 2004, and the C/Sao Paulo/378/82 from 2006 to 2012. When compared to the other antigenic groups, the seroprevalence of the C/Sao Paulo/378/82 group was lower in 2001 for individuals older than 5 years and was higher in 2011 in individuals younger than 40 years. Conclusions The results from our study suggest that epidemics of influenza C virus infection periodically occur and the replacement of the dominant antigenic group may be caused by immune selection within older children and/or adults in the community. |
| Databáze: | OpenAIRE |
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