Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice
| Autor: | Mathias Lucas, Dominique Figarella-Branger, Eric Vivier, Laurent Daniel, Sophie Guia, Nicole Horschowski, Naoko Aoki, Elena Tomasello, Sophie Gomez |
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| Rok vydání: | 2002 |
| Předmět: |
Genetically modified mouse
Lipopolysaccharides Myeloid Lymphoid Tissue Neutrophils Transgene Immunology Gene Expression Inflammation Mice Transgenic Biology Mice Bone Marrow Lymphopenia medicine Immunology and Allergy Animals Humans Genetic Predisposition to Disease Tyrosine Receptors Immunologic Receptor Lung Immunodeficiency Adaptor Proteins Signal Transducing Mice Knockout Wasting Syndrome Macrophages Membrane Proteins medicine.disease Shock Septic Neutrophilia Hematopoiesis Mice Inbred C57BL medicine.anatomical_structure medicine.symptom |
| Zdroj: | European journal of immunology. 32(9) |
| ISSN: | 0014-2980 |
| Popis: | KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myeloid and lymphoid compartments. KARAP/DAP12-transgenic mice present, in a transgene dose-dependent manner, a complex phenotype characterized by two independent and spontaneous hematological abnormalities: (i) a severe lymphopenia and (ii) a massive inflammatory syndrome associated with neutrophilia and lung infiltration by multinucleated macrophages. These myeloid abnormalities observed in KARAP/DAP12-transgenic mice indicate that KARAP/DAP12-driven signals are critically involved in inflammation, and constitute an essential target to control the resolution of inflammatory disorders based on monocytes/macrophages and neutrophils. |
| Databáze: | OpenAIRE |
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