The nucleotide sequence of cDNA coding for preproinsulin from the primate Macacafascicularis
| Autor: | Jürgen Dr. Groneberg, Michael Leineweber, Friedrich Dr. Wengenmayer, Wetekam Waldemar, Ernst-Ludwig Winnacker |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Untranslated region
endocrine system Preproinsulin Biology Complementary DNA Escherichia coli Genetics Animals Insulin Coding region Amino Acid Sequence RNA Messenger Protein Precursors Peptide sequence Messenger RNA Base Sequence Nucleic acid sequence RNA DNA General Medicine Molecular biology Macaca fascicularis Protein Biosynthesis Poly A hormones hormone substitutes and hormone antagonists Plasmids Proinsulin |
| Zdroj: | Gene. 19:179-183 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/0378-1119(82)90004-x |
| Popis: | DNA complementary to preproinsulin messenger RNA from the primate Macaca fascicularis has been cloned into the PstI endonuclease site of the plasmid pBR322. One clone contains the entire preproinsulin coding region as well as 59 nucleotides of the 5'-untranslated region. The results predict an amino acid sequence for the Macaca fascicularis preproinsulin and establish for the first time that the primary structures of human and primate insulins are identical. The two amino acid exchanges between human and primate preproinsulins are restricted to the pre- and the C-peptide, respectively. |
| Databáze: | OpenAIRE |
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