Cumulative renal tubular damage associated with cisplatin nephrotoxicity
| Autor: | Marshall P. Goren, Marc E. Horowitz, Reba K. Wright |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Adolescent Urinary system Urology CD13 Antigens Toxicology Aminopeptidases Nephrotoxicity Excretion chemistry.chemical_compound Internal medicine Acetylglucosaminidase medicine Humans Pharmacology (medical) Child Pharmacology Cisplatin Creatinine Proteinuria Kidney Tubules Endocrinology Oncology chemistry Child Preschool Toxicity Female Alanine aminopeptidase medicine.symptom medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 18:69-73 |
| ISSN: | 1432-0843 0344-5704 |
| Popis: | We assessed the acute and chronic effect of multiple courses of cisplatin therapy on renal tubules by monitoring the urinary excretion of alanine aminopeptidase, N-acetyl-beta-D-glucosaminidase, and total protein. Urine specimens were obtained before and after doses of cisplatin (90 mg/m2) given to 12 patients. Each dose of cisplatin induced transient increases in enzyme excretion, followed by proteinuria 3-5 days later. Transient enzymuria after the last cisplatin dose was significantly greater than that after the first dose. Moreover, persistent increases in urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations over pretherapy levels indicated chronic renal tubular damage. Our findings disclosed striking differences between patients in susceptibility to progressive nephrotoxicity. |
| Databáze: | OpenAIRE |
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