Melanoma models for the next generation of therapies
| Autor: | Ze'ev Ronai, Leonard I. Zon, Carmit Levy, Meenhard Herlyn, Marcus Bosenberg, Amanda W. Lund, David B. Lombard, Jean-Christophe Marine, Richard M. White, Yardena Samuels, Charles K. Kaufman, Christin E. Burd, Shaheen Khan, Marc Hurlbert, Kristen L. Mueller, Eleonora Leucci, Andrew E. Aplin, Sheri L. Holmen, Iwei Yeh, Ashani T. Weeraratna, David J. Adams, Martin McMahon, Corine Bertolotto, Florian A. Karreth, Sebastian Kobold, Glenn Merlino, Carla Daniela Robles-Espinoza, Ping Chi, Jessie Villanueva, Niroshana Anandasabapathy, Kerrie L. Marie, Maria S. Soengas, Jiyue Zhu, Richard Marais, Craig J. Ceol, E. Elizabeth Patton |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Drug resistance Article Targeted therapy Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Skin Neoplasms/drug therapy Tumor Microenvironment medicine Tumor Microenvironment/immunology Animals Humans Melanoma/drug therapy Melanoma neoplasms Immunity/immunology Tumor microenvironment business.industry Immunity Cell Biology Immunotherapy medicine.disease 3. Good health Clinical trial Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis Genetically Engineered Mouse Immunotherapy/methods business |
| Zdroj: | Patton, E E, Mueller, K L, Adams, D J, Anandasabapathy, N, Aplin, A E, Bertolotto, C, Bosenberg, M, Ceol, C, Chi, P, Herlyn, M, Holmen, S L, Karreth, F A, Kaufman, C, Khan, S, Kobold, S, Leucci, E, Levy, C, Lombard, D B, Lund, A W, Marie, K L, Marine, J-C, Marais, R, McMahon, M, Robles-Espinoza, C D, Ronai, Z A, Samuels, Y, Soengas, M S, Villanueva, J, Weeraratna, A T, White, R M, Yeh, I, Zhu, J, Zon, L I, Hurlbert, M S & Merlino, G 2021, ' Melanoma Models for the Next Generation of Therapies ', Cancer Cell . https://doi.org/10.1016/j.ccell.2021.01.011 Cancer Cell Patton, E E, Mueller, K L, Adams, D J, Anandasabapathy, N, Aplin, A E, Bertolotto, C, Bosenberg, M, Ceol, C J, Burd, C E, Chi, P, Herlyn, M, Holmen, S L, Karreth, F A, Kaufman, C K, Khan, S, Kobold, S, Leucci, E, Levy, C, Lombard, D B, Lund, A W, Marie, K L, Marine, J-C, Marais, R, McMahon, M, Robles-Espinoza, C D, Ronai, Z A, Samuels, Y, Soengas, M S, Villanueva, J, Weeraratna, A T, White, R M, Yeh, I, Zhu, J, Zon, L I, Hurlbert, M S & Merlino, G 2021, ' Melanoma models for the next generation of therapies ', Cancer Cell, vol. 39, no. 5, pp. 610-631 . https://doi.org/10.1016/j.ccell.2021.01.011 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccell.2021.01.011 |
| Popis: | Summary There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of novel therapeutic modalities. Here, we discuss the current state of the art of melanoma models including genetically engineered mouse, patient-derived xenograft, zebrafish, and ex vivo and in vitro models. We also identify five major challenges that can be addressed using such models, including metastasis and tumor dormancy, drug resistance, the melanoma immune response, and the impact of aging and environmental exposures on melanoma progression and drug resistance. Additionally, we discuss the opportunity for building models for rare subtypes of melanomas, which represent an unmet critical need. Finally, we identify key recommendations for melanoma models that may improve accuracy of preclinical testing and predict efficacy in clinical trials, to help usher in the next generation of melanoma therapies. |
| Databáze: | OpenAIRE |
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