Comparison of Effects of Hemostatic Gelatin Sponge Impregnated with Ropivacaine versus Normal Saline Applied on the Transverse Process of the Operated Vertebrae on Postoperative Pain in Patients Undergoing Spinal Instrumentation Surgery: A Randomized Clinical Trial
| Autor: | Monique J. Chammas, Georges N. Mezher, Marc M. Ghabach, Morad R. Abou Al Ezz, Nakhle E. Mhanna, Maroun B. Ghabach |
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| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty Meperidine Visual analogue scale medicine.medical_treatment Postoperative pain Hemostatics law.invention 03 medical and health sciences Intraoperative Period 0302 clinical medicine Lumbar Randomized controlled trial Double-Blind Method law medicine Humans Ropivacaine Anesthetics Local Saline Aged Absorbable gelatin sponge Pain Postoperative Lumbar Vertebrae business.industry Middle Aged Gelatin Sponge Absorbable Vertebra Surgery Analgesics Opioid medicine.anatomical_structure Spinal Fusion Treatment Outcome 030220 oncology & carcinogenesis Female Neurology (clinical) Saline Solution business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | World neurosurgery. 128 |
| ISSN: | 1878-8769 |
| Popis: | Background Protocols for effective postoperative pain control in patients undergoing spinal surgery are not standardized. In our study, we compared the effects of hemostatic absorbable gelatin sponge impregnated with ropivacaine versus normal saline when applied to the transverse process of the operated vertebrae on the postoperative pain following instrumentation spine surgery. Methods A prospective double-blind randomized study was conducted on 30 patients undergoing spine surgery. At the end of surgery, the hemostatic gelatin sponge was applied by the surgeon on the transverse process of the operated vertebra containing either ropivacaine 0.5% or normal saline NaCl 0.9. Pain was assessed using the visual analog scale (VAS) every 4 hours for 48 hours postoperatively in the 2 groups (ropivacaine vs. normal saline). The total amount of postoperative opioid use was also recorded. Results The VAS score was significantly lower in patients receiving hemostatic gelatin sponge impregnated with local anesthetics as compared with patients receiving gelatin sponge impregnated with normal saline 48 hours postoperatively; the mean total dose of meperidine given in the first 48 hours postoperatively was significantly lower (53.5 ± 51.0 mg) in patients receiving gelatin sponge impregnated with local anesthetics as compared with patients receiving hemostatic gelatin sponge impregnated with normal saline (140.5 ± 102 mg). Conclusions Use of intraoperative hemostatic gelatin sponge impregnated with ropivacaine applied on the transverse process of the operated vertebrae intraoperatively resulted in decreasing the postoperative pain in patients undergoing lumbar instrumentation surgery as manifested by the decrease in the VAS score and the total dose of opioids. |
| Databáze: | OpenAIRE |
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