High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass
| Autor: | Irum Zeb Jan, Lina E. Aguirre, Reina Armamento-Villareal, Kenneth Fowler, Clifford Qualls, David Robbins, Georgia Colleluori, Kenneth Villareal, Dennis T. Villareal |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Globulin Endocrinology Diabetes and Metabolism Abdominal Fat Article Body Mass Index Aromatase Endocrinology Bone Density Internal medicine medicine Humans Testosterone Aged Bone mineral biology business.industry Hypogonadism General Medicine Low testosterone Baseline data Middle Aged Enzyme Activation Cross-Sectional Studies Body Composition biology.protein Lean body mass business Automated immunoassay Biomarkers |
| Zdroj: | Eur J Endocrinol |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveBecause the aromatase enzyme catalyzes the conversion of testosterone to estradiol (E2), the activity of this enzyme could be important in the musculoskeletal health of men with low testosterone. The objective of the present study is to determine the influence of aromatase activity on the bone mineral density (BMD) and body composition of patients with hypogonadism.DesignCross-sectional study.MethodsThe baseline data of 90 patients between 40 and 74 years old who participated in a genetic study of response to testosterone therapy in men with low testosterone (i.e., 2was measured by ultrasensitive enzyme immunoassay, and sex hormone-binding globulin was measured by enzyme immunoassay.ResultsMen in the highest tertile of E2to testosterone ratio (E2:T) had the highest spine BMD (P≤0.037), highest truncal fat (P=0.046), and lowest truncal lean body mass (P=0.045). A similar pattern was observed in the upper extremities; that is, fat mass significantly increased (P=0.047), whereas lean mass significantly decreased (P=0.034) with increasing E2:T tertiles.ConclusionThe present findings suggest that in men with hypogonadism, aromatase activity could be an important determinant of musculoskeletal health. Men with high aromatase activity are able to maintain a higher BMD despite low circulating testosterone, but they have lower lean and higher truncal fat mass as compared to those with lower aromatase activity. |
| Databáze: | OpenAIRE |
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