An exercise trial to reduce cancer related fatigue in African American breast cancer patients undergoing radiation therapy: Design, rationale, and methods
Autor: | Chiranjeev Dash, Mary Mills, Claudine Isaacs, Kepher H. Makambi, Pamela Randolph-Jackson, Lucile L. Adams-Campbell, Vivian V. Watkins |
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Rok vydání: | 2016 |
Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Breast Neoplasms Article Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Clinical Protocols Quality of life medicine Humans Aerobic exercise Pharmacology (medical) Prospective Studies 030212 general & internal medicine Young adult Radiation Injuries Prospective cohort study Cancer-related fatigue Fatigue Aged business.industry General Medicine Middle Aged medicine.disease Exercise Therapy Black or African American Radiation therapy Clinical trial Research Design 030220 oncology & carcinogenesis Quality of Life Physical therapy Female medicine.symptom business |
Zdroj: | Contemporary Clinical Trials. 47:153-157 |
ISSN: | 1551-7144 |
Popis: | Background Cancer related fatigue (CRF) is a common and debilitating side-effect of radiotherapy in breast cancer patients. Physical activity interventions can attenuate CRF but evidence in African–American women with breast cancer is lacking. Methods/design The “Pedlar” Study is a prospective, 8-week structured moderate-intensity exercise intervention, delivered concurrently with radiotherapy, to reduce CRF and improve health-related quality of life among African American breast cancer patients. Forty African American women with breast cancer scheduled to receive radiation therapy at MedStar Washington Hospital Center will be randomized to one of the two trial arms: 1) a facility-based aerobic exercise utilizing a portable stationary pedal exerciser; and 2) a control group. Intervention arm participants will exercise at the hospital either before or after their radiation treatment. Assessments will be conducted at baseline, 4, and 8 weeks. The outcome variables are CRF, biomarkers of inflammation, and health-related quality of life. Discussion The Pedlar Study will provide preliminary evidence on whether a short-term moderate-intensity exercise intervention might be effective in reducing CRF in African American women undergoing radiotherapy for breast cancer, and whether this effect is mediated by inflammation. |
Databáze: | OpenAIRE |
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