Thermodynamic Activity-Based Solvent Design for Bioreactions
| Autor: | Gabriele Sadowski, Anton Wangler, Christoph Held |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Activity coefficient Chemistry Kinetics Alcohol Dehydrogenase Thermodynamics Bioengineering 02 engineering and technology Models Theoretical 021001 nanoscience & nanotechnology Michaelis–Menten kinetics Enzymes Solvent 03 medical and health sciences 030104 developmental biology Biocatalysis Solvents 0210 nano-technology Biotechnology |
| Zdroj: | Trends in Biotechnology. 37:1038-1041 |
| ISSN: | 0167-7799 |
| DOI: | 10.1016/j.tibtech.2019.04.015 |
| Popis: | To improve the kinetics of enzyme-catalyzed reactions, cosolvents are commonly added to reaction mixtures. The search for a good cosolvent is still empirical and experimentally based. We discuss a thermodynamic activity-based approach that improves biocatalytic processes by predicting cosolvent influences on Michaelis constants, ultimately reducing time and cost. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect