Role of Neuropeptide Y in Cold Stress-Induced Hypertension
| Autor: | Thomas C. Westfall, Chun-Lian Yang, Linda Naes, Yu-mei Wu, Bryan F. Cox, Xiaoli Chen, Song-Ping Han |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Physiology Gene Expression Blood Pressure Biochemistry Rats Sprague-Dawley Cellular and Molecular Neuroscience Endocrinology Heart Rate Stress Physiological Rats Inbred SHR Internal medicine Adrenal Glands mental disorders Gene expression Heart rate medicine Animals Neuropeptide Y Cold stress Messenger RNA business.industry Antagonist Neuropeptide Y receptor humanities Rats Receptors Neuropeptide Y Cold Temperature Blood pressure Hypertension business |
| Zdroj: | Peptides. 19:351-358 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(97)00297-0 |
| Popis: | Chronic cold stress (4 degrees C) produced a sustained increase in mean arterial pressure in both normotensive and borderline hypertensive rats (BHR). The high blood pressure in BHRs was significantly reversed by a neuropeptide Y (NPY) Y1 receptor antagonist suggesting that NPY is involved in mediating stress-induced hypertension. Corresponding increases in adrenal NPY messenger RNA and NPY immunoreactivity were found during the stress; furthermore, chronic cold stress also potentiated the pressor response of rats to a subsequent acute stress test in which NPY has been shown to play a role. These results suggest that chronic cold stress-induced hypertension is mediated by elevated NPY release and vascular tone as a result of increased NPY gene expression and storage. |
| Databáze: | OpenAIRE |
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